Please use this identifier to cite or link to this item: http://repository.unizik.edu.ng/handle/123456789/435
Title: The Synergistic Potentials of Platostoma africanum and Psidium guajavaagainst Some Multi-drug Resistant Bacteria
Authors: Chimezie, Chinenye C.
Eze, Peter M.
Abba, Chika C.
Onyegbule, Felix A.
Esimone, Charles O.
Keywords: Antimicrobial synergism
Psidium guajava
multi-drug resistance
Platostoma africanum
Issue Date: 3-Apr-2017
Publisher: SCIENCEDOMAIN International
Citation: European Journal of Medicinal Plants 18(3): 1-12, 2017
Abstract: Assessment of synergism of the plant combinations against the test isolates was done by the checkerboard method. Their fractional inhibitory concentrations (FICs) indices were calculated and used to indicate synergism against the test organisms. Results: P. guajavashowed broad antibacterial activity against both groups of resistant organisms. P. africanumshowed poor antimicrobial activity against the Gram-negative organisms compared to the Gram-positive strains. Determination of bactericidal activity of the extracts on the test isolates showed that the killing ability of the plants was time dependent. Most combination ratios of the plant extracts showed synergism against ESBL-producing E. colistrains and additivity against MRSA. The 8:2 (P. guajava: P. africanum) combination showed synergism against all the test isolates, with FIC indices ranging from 0.106 to 0.825. Conclusions: P. guajavaand P. africanum(8:2) combination has synergistic and broad spectrum antibacterial activity against ESBL-producing Escherichia coliand MRSA. The possibility of using the combination for disinfection is foreseeable. Characterization of the active principles from these plants is needed.
Description: Scholarly Work
URI: DOI: 10.9734/EJMP/2017/32235
http://repository.unizik.edu.ng/handle/123456789/435
ISSN: 2231-0894
Appears in Collections:Scholarly Works

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