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Title: | Antimotility effects of extracts and fractions of Eastern Nigeria mistletoe (Loranthus micranthusLinn) |
Authors: | Osadebe, Patience O Abba, Chika C Agbo, Matthias O |
Keywords: | Loranthus micranthus Fractination Gastrointestinal transit Atropine |
Issue Date: | 20-Jul-2012 |
Publisher: | Elsevier |
Citation: | Asian Pacific Journal of Tropical Medicine (2012)556-560 |
Abstract: | Objective: To evaluate the antimotility activity of Eastern Nigerian mistletoe[Loranthus micranthus (L. micranthus) Linn] parasitic on six different host trees viz. Baphia nitida, Persia americana, Kola accuminata, Irvingia gabonensis, Citrus simensisand Pentacletra macrophylla (P. mycrophylla). Methods: The antimotility of the methanol extracts and solvent fractions were evaluated in castor oil induced diarrheoa in rats. Results: The methanol extracts (200mg/kg, i.p.)inhibited defeacation significantly (P< 0.05) 4h after administration (75.73%to 93.33%)more than that of atropine sulphate (2mg/kg, i.p.)which inhibited defeacation by 80.0%. The methanol extract (200mg/kg, i.p.)of L. micranthusparasitic on P. mycrophyllaexhibited significant (P<0.05)inhibition in gastrointestinal transit (67.6%)more than that of atropine sulphate (2mg/kg, i.p.)which inhibited gastrointestinal transit by 26.4%. The solvent fractions ofL. micranthusparasitic on P. mycrophyllaat dose levels of 150mg/kg inhibited significantly the gastrointestinal transit of mice. Fraction F5exhibited inhibitory activity which was comparable to loperamide (73.3%). Conclusions: The methanol extract of L. micranthusparasitic on P. macrophyllaexhibits higher antimotility activity that other extracts. The solvent fractions could serve as source of novel antimotility agents. |
Description: | Scholarly Work |
URI: | DOI:10.1016/S1995-7645(12)60098-4 http://repository.unizik.edu.ng/handle/123456789/433 |
Appears in Collections: | Scholarly Works |
Files in This Item:
File | Description | Size | Format | |
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ABBA CHIKA C. 3.pdf | 300.32 kB | Adobe PDF | View/Open |
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