Please use this identifier to cite or link to this item: http://repository.unizik.edu.ng/handle/123456789/433
Title: Antimotility effects of extracts and fractions of Eastern Nigeria mistletoe (Loranthus micranthusLinn)
Authors: Osadebe, Patience O
Abba, Chika C
Agbo, Matthias O
Keywords: Loranthus micranthus
Fractination
Gastrointestinal transit
Atropine
Issue Date: 20-Jul-2012
Publisher: Elsevier
Citation: Asian Pacific Journal of Tropical Medicine (2012)556-560
Abstract: Objective: To evaluate the antimotility activity of Eastern Nigerian mistletoe[Loranthus micranthus (L. micranthus) Linn] parasitic on six different host trees viz. Baphia nitida, Persia americana, Kola accuminata, Irvingia gabonensis, Citrus simensisand Pentacletra macrophylla (P. mycrophylla). Methods: The antimotility of the methanol extracts and solvent fractions were evaluated in castor oil induced diarrheoa in rats. Results: The methanol extracts (200mg/kg, i.p.)inhibited defeacation significantly (P< 0.05) 4h after administration (75.73%to 93.33%)more than that of atropine sulphate (2mg/kg, i.p.)which inhibited defeacation by 80.0%. The methanol extract (200mg/kg, i.p.)of L. micranthusparasitic on P. mycrophyllaexhibited significant (P<0.05)inhibition in gastrointestinal transit (67.6%)more than that of atropine sulphate (2mg/kg, i.p.)which inhibited gastrointestinal transit by 26.4%. The solvent fractions ofL. micranthusparasitic on P. mycrophyllaat dose levels of 150mg/kg inhibited significantly the gastrointestinal transit of mice. Fraction F5exhibited inhibitory activity which was comparable to loperamide (73.3%). Conclusions: The methanol extract of L. micranthusparasitic on P. macrophyllaexhibits higher antimotility activity that other extracts. The solvent fractions could serve as source of novel antimotility agents.
Description: Scholarly Work
URI: DOI:10.1016/S1995-7645(12)60098-4
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