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DC Field | Value | Language |
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dc.contributor.author | Abubakar, Abdullahi Rabiu | - |
dc.contributor.author | Ahmad, Rahnuma | - |
dc.contributor.author | Rowaiye, Adekunle Babajide | - |
dc.contributor.author | Rahman, Sayeeda | - |
dc.contributor.author | Iskandar, Katia | - |
dc.contributor.author | Dutta, Siddhartha | - |
dc.contributor.author | Oli, Angus Nnamdi | - |
dc.contributor.author | Dhingra, Sameer | - |
dc.contributor.author | Tor, Maryam Abba | - |
dc.contributor.author | Etando, Ayukafangha | - |
dc.contributor.author | Kumar, Santosh | - |
dc.contributor.author | Irfan, Mohammed | - |
dc.contributor.author | Gowere, Marshall | - |
dc.contributor.author | Chowdhury, Kona | - |
dc.contributor.author | Akter, Farhana | - |
dc.contributor.author | Jahan, Dilshad | - |
dc.contributor.author | Schellack, Natalie | - |
dc.contributor.author | Haque, Mainul | - |
dc.date.accessioned | 2023-04-12T14:15:14Z | - |
dc.date.available | 2023-04-12T14:15:14Z | - |
dc.date.issued | 2022-03-25 | - |
dc.identifier.citation | Life, 12, 478. | en_US |
dc.identifier.uri | https://doi.org/10.3390/life12040478 | - |
dc.identifier.uri | http://repository.unizik.edu.ng/handle/123456789/536 | - |
dc.description | Scholarly Work | en_US |
dc.description.abstract | COVID-19-infected patients require an intact immune system to suppress viral replication and prevent complications. However, the complications of SARS-CoV-2 infection that led to death were linked to the overproduction of proinflammatory cytokines known as cytokine storm syndrome. This article reported the various checkpoints targeted to manage the SARS-CoV-2-induced cytokine storm. The literature search was carried out using PubMed, Embase, MEDLINE, and China National Knowledge Infrastructure (CNKI) databases. Journal articles that discussed SARS-CoV-2 infection and cytokine storm were retrieved and appraised. Specific checkpoints identified in managing SARS-CoV-2 induced cytokine storm include a decrease in the level of Nod-Like Receptor 3 (NLRP3) inflammasome where drugs such as quercetin and anakinra were effective. Janus kinase-2 and signal transducer and activator of transcription-1 (JAK2/STAT1) signaling pathways were blocked by medicines such as tocilizumab, baricitinib, and quercetin. In addition, inhibition of interleukin (IL)-6 with dexamethasone, tocilizumab, and sarilumab effectively treats cytokine storm and significantlyreduces mortality caused by COVID-19. Blockade of IL-1 with drugs such as canakinumab and anakinra, and inhibition of Bruton tyrosine kinase (BTK) with zanubrutinib and ibrutinib was also beneficial. These agents' overall mechanisms of action involve a decrease in circulating proinflammatory chemokines and cytokines and or blockade of their receptors. Consequently, the actions of these drugs significantly improve respiration and raise lymphocyte count and PaO2/FiO 2ratio.Targeting cytokine storms' pathogenesis genetic and molecular apparatus will substantially enhance lung function and reduce mortality due to the COVID-19 pandemic. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Multidisciplinary Digital Publishing Institute | en_US |
dc.subject | cytokine storm | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | pathogenesis | en_US |
dc.subject | immune response | en_US |
dc.subject | interleukins | en_US |
dc.subject | hyperinflammation | en_US |
dc.title | Targeting Specific Checkpoints in the Management of SARS-CoV-2 Induced Cytokine Storm | en_US |
dc.type | Article | en_US |
Appears in Collections: | Scholarly Works |
Files in This Item:
File | Description | Size | Format | |
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OLI ANGUS NNAMDI 18.pdf | 3.65 MB | Adobe PDF | View/Open |
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