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dc.contributor.authorOsadebe, Patience O-
dc.contributor.authorAbba, Chika C-
dc.contributor.authorAgbo, Matthias O-
dc.date.accessioned2023-02-06T17:49:13Z-
dc.date.available2023-02-06T17:49:13Z-
dc.date.issued2012-07-20-
dc.identifier.citationAsian Pacific Journal of Tropical Medicine (2012)556-560en_US
dc.identifier.uriDOI:10.1016/S1995-7645(12)60098-4-
dc.identifier.urihttp://repository.unizik.edu.ng/handle/123456789/433-
dc.descriptionScholarly Worken_US
dc.description.abstractObjective: To evaluate the antimotility activity of Eastern Nigerian mistletoe[Loranthus micranthus (L. micranthus) Linn] parasitic on six different host trees viz. Baphia nitida, Persia americana, Kola accuminata, Irvingia gabonensis, Citrus simensisand Pentacletra macrophylla (P. mycrophylla). Methods: The antimotility of the methanol extracts and solvent fractions were evaluated in castor oil induced diarrheoa in rats. Results: The methanol extracts (200mg/kg, i.p.)inhibited defeacation significantly (P< 0.05) 4h after administration (75.73%to 93.33%)more than that of atropine sulphate (2mg/kg, i.p.)which inhibited defeacation by 80.0%. The methanol extract (200mg/kg, i.p.)of L. micranthusparasitic on P. mycrophyllaexhibited significant (P<0.05)inhibition in gastrointestinal transit (67.6%)more than that of atropine sulphate (2mg/kg, i.p.)which inhibited gastrointestinal transit by 26.4%. The solvent fractions ofL. micranthusparasitic on P. mycrophyllaat dose levels of 150mg/kg inhibited significantly the gastrointestinal transit of mice. Fraction F5exhibited inhibitory activity which was comparable to loperamide (73.3%). Conclusions: The methanol extract of L. micranthusparasitic on P. macrophyllaexhibits higher antimotility activity that other extracts. The solvent fractions could serve as source of novel antimotility agents.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectLoranthus micranthusen_US
dc.subjectFractinationen_US
dc.subjectGastrointestinal transiten_US
dc.subjectAtropineen_US
dc.titleAntimotility effects of extracts and fractions of Eastern Nigeria mistletoe (Loranthus micranthusLinn)en_US
dc.typeArticleen_US
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