THE PHARMACEUTICAL CONSTITUENTS OF CRATEVA ADANSONII LEAF (OGWU OKU)

Abstract

he elucidation of the crade drug of Crateva adansonii, family: Capparidaceae) leaves was carried out in terms of physico-chemical and biological techniques. Phytochemical screening showed the presence of sapremins tannins, flavonoids alkaloids and steroids. The Fourier Transform Infrared Spectral analysis showed the compound contained aromatic amides, esters,ethers and conjugated ethers. The TLC analysis of the extracted alkaloid gave Rf value of 0.93 in the methanol ammonia solvent. The AAS of the crude sample showed the presence of some metals such as Ca,Mg.Na, Fe,Zn, Pb, Mn Cr, Cu and Cd in the decreasing order of their concentrations. Its alkaloid melting point was 250°C. Various fractions of the crude drug extracted had antimicrobial activity against E.col S.aureus and Salmonella spp. Its effect was more at a high concentration of 600mg/ml. The suggested active alkaloid ingredient might be an indole-amide from the FTIR, TLC and the melting point results.